Health and Toxicology Studies
Krieger S; Day B; Kuhl A; Spence M
Suitability of the Direct Peptide Reactivity Assay (DPRA) for assessing chemical sensitization potential of aromatic polymeric polyisocyanate pre-polymer (P3) substances
Poster presented at the 62nd Annual Meeting of the Society of Toxicology (SOT), Nashville, Tennessee, USA, 19-23 Mar., 2023
[no DOI]
Plehiers PM
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Toxicol Ind Health, Vol. 38, (9), 2022, 493-4
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Saf Health Work, Vol. 13, (1), 2022, 129-30
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Spence MW; Plehiers PM
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Am J Ind Med, Vol. 64, (12), 2021, 1053-4
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Spence MW; Plehiers PP
A brief overview of properties and reactions of diisocyanates
Toxicol Ind Health, Vol. 38, (9), 2022, 495-9
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West RJ; Burleson S; Gulledge T; Miller JW; Chappelle AH; Krieger S; Graham C; Snyder S; Simon G; Plehiers PM
Exploring structure/property relationships to health and environmental hazards of polymeric polyisocyanate prepolymer substances-2. Dermal sensitization potential in the mouse local lymph node assay
Toxicol Ind Health, Vol. 38, (9), 2022, 556-77
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Antoniou EE; Zeegers MP
The relationship between toluene diisocyanate exposure and respiratory health problems: a meta-analysis of epidemiological studies
Toxicol Ind Health, Vol. 38, (9), 2022, 595-605
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Dekant W; Colnot T
Evaluation of animal toxicity studies with diisocyanates regarding presence of thresholds for induction and elicitation of respiratory allergy by quantitative weight of evidence
Toxicol Ind Health, Vol. 38, (9), 2022, 578-94
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Schupp T; Plehiers PM
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Toxicol Ind Health, Vol. 38, (9), 2022, 500-28
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Unterberger-Henig, E
Comparative evaluation of three methylene dianiline isomers in the bacterial reverse mutation assay, the in vitro gene mutation test, and the in vitro chromosomal aberration test
Toxicol Ind Health, Vol. 38, (9), 2022, 529-43
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Bartels M; van Osdol W; Le Merdy M; Chappelle A; Kuhl A; West R
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Regul Toxicol Pharmacol, 129, 2022, 105117
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Ji Z; Koehler MW; Scott AB; LeBaron MJ
Assessment of cellular and molecular metrics for dose selection in an in vivo comet assay: a case study with MDI
Environ Mol Mutagen, Vol. 62, (8), 2021, 446-57
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Wisnewski AV; Liu J; Nassar AF
LC-UV-MS and MS/MS characterize glutathione reactivity with different isomers (2,2’ and 2,4’ vs. 4,4’) of methylene diphenyl-diisocyanate
EC Pharmacol Toxicol, Vol. 7, (3), 2019, 205-19
[no DOI]
Prueitt RL; Lynch HN; Mohar I; Goodman JE
Critical evaluation of threshold for respiratory effects of toluene diisocyanate
Poster presented at EUROTOX 2018: 54th Congress of the European Societies of Toxicology, Brussels, Belgium, 2-5 Sep., 2018
[no DOI]
Prueitt RL; Lynch HN; Zu K; Shi L; Goodman, JE
Dermal exposure to toluene diisocyanate and respiratory cancer risk
Environ.Int., Vol. 109, 2017, 181-92
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American Chemistry Council (ACC) Diisocyanates Panel; Bernstein DI
A guide for the primary care physician in evaluating diisocyanate exposed workers
Infographic, 2017, https://dii.americanchemistry.com/Infographic-Guide-For-Primary-Care-Physicians-To-Evaluate-Diisocyanate-Exposed-Workers-For-Occupational-Asthma.pdf
[no DOI]
Bernstein DI; Jolly A; Spence M
A guide for the primary care physician in evaluating diisocyanate exposed workers
Presentation, American College of Occupational and Environmental Medicine (ACOEM) American Occupational Health Conference (AOHC), Denver, Colorado, USA, 23-6 Apr., 2017
[no DOI]
Goodman JE; Zu K; Loftus CT; Prueitt R
Dermal TDI exposure is not associated with lung cancer risk
Am.J.Ind.Med., Vol. 60, (2), 2017, 221-2
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Prueitt R; Rhomberg LR; Guan N; Goodman JE; Xiaowei J
Evaluation of the carcinogenicity of toluene diisocyanate
Asian.J.Ecotoxicol., Vol. 11, (4), 2016, 26-60
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Chappelle AH; Spence M; Tury B
Letter to the editor RE: Wolf et al.
Crit.Rev.Toxicol., Vol. 46, (10), 2016, 911-2
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Pauluhn J
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Poster, Society of Toxicology (SOT) 54th Annual Meeting & ToxExpo, San Diego, California, USA, 22-26 Mar., 2015
[no DOI]
Guan N
A hypothesis-based weight-of-evidence approach to evaluate the human carcinogenicity of TDI
Presentation, International Summit on Health and Environmental Risk Assessment, the First Training Course on Regulatory Toxicology and Risk Assessment, Guangzhou, China, 11 Mar., 2015
[no DOI]
Hughes MA; Carson M; Collins MA; Jolly AT; Molenaar DM; Steffens W; Swaen GM
Does diisocyanate exposure result in neurotoxicity?
Clin.Toxicol., Vol. 52, (4), 2014, 242-57
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Luna LG; Green BJ; Zhang F; Arnold SM; Siegel PD; Bartels MJ
Quantitation of 4,4'-methylene diphenyl diisocyanate human serum albumin adducts
Toxicol.Rep., Vol. 1, 2014, 743-751
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Luna LG; Markham DA; Bartels MJ; Brzak KA
Feasibility of biomonitoring methylene diphenyl diisocyanate adducted to lysine amino acids in rat urine
Poster, 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, Maryland, USA, 15-19 Jun., 2014
[no DOI]
Pauluhn J.
Development of a respiratory sensitization/elicitation protocol of toluene diisocyanate (TDI) in Brown Norway rats to derive an elicitation-based occupational exposure level
Toxicol., Vol. 319, 2014, 10-22
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Prueitt RL; Rhomberg LR; Goodman JE
Hypothesis-based weight-of-evidence evaluation of the human carcinogenicity of toluene diisocyanate
Crit.Rev.Toxicol., Vol. 43, (5), 2013, 391-435
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Poole A; Chappelle AH; Collins MA
Mechanisms for the development of rat lung tumors following inhalation exposures to MDI
Poster, Society of Toxicology 53 rd Annual Meeting and ToxExpo, Phoenix, AZ, 23-27 March, 2014
[no DOI]
Prueitt RL; Goodman JE; Rhomberg LR
Hypothesis-based weight-of-evidence evaluation of the human carcinogenicity of toluene diisocyanate
Poster, Society of Toxicology 52 nd Annual Meeeting and ToxExpo, San Antonio, TX, 10-14 March, 2013
[no DOI]
Luna LG; Green BJ; Zhang F; Siegel PD; Bartels MJ
Enrichment and measurement of a signature MDI HSA peptide adduct
Poster, CIRPD Conference on Isocyanates and Health: Past, Present and Future, 3-4 April, 2013
[no DOI]
Arnold SM; Collins MA; Graham C; Jolly AT; Parod RJ; Poole A; Schupp T; Shiotsuka RN; Woolhiser MR
Risk assessment for consumer exposure to toluene diisocyanate (TDI) derived from polyurethane flexible foam
Reg.Toxicol.Pharmacol., Vol. 64, (3), Dec., 2012, 504-15
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Sielken RL; Bretzlaff RS; Valdez-Flores C; Parod R
Statistical comparison of carcinogenic effects and dose-response relationships in rats and mice for 2,4-toluene diamine to those ascribed to toluene diisocyanate
Hum.Ecol.Risk Assess., Vol. 18, (6), Nov., 2012, 1315-37
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Schupp T and Collins MA
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EXCLI J., Vol.11, 24 Jul., 2012, 416-35
[no DOI]
Pauluhn J
Interrelating the acute and chronic mode of action of inhaled methylenediphenyldiisocyanate (MDI) in rats assisted by computational toxicology.
Reg.Toxicol.Pharmacol., Vol. 61, 2011, 351-64
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Pauluhn J and Poole A
Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MD): determination of the elicitation threshold concentration of after inhalation sensitization
Toxicol., Vol. 281, 2011, 15-24
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Hoffman HD; Leibold E; Ehnes C; Fabian E; Landsiedel R; Gamer A; Poole A
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Clinical signs and histopathology following dermal exposure of male rats to TDI
Toxicol.Lett., Vol 199, 2010, 364-71
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Pauluhn J
Brown Norway rat asthma model of diphenylmethane - 4,4'- diisocyanate (MDI): analysis of the elicitation dose-response relationship
Toxicol.Sci. Vol.104 (2) Aug, 2008, 320-31
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Ott MG; Jolly AT; Burkert AL; Brown WE
Issues in diisocyanate antibody testing
Critical Reviews in Toxicology, Vol. 37, 2007, 567-585
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Zeiger E and Woolhiser M
The genetic toxicity of diisocyanates in humans and laboratory animals
Poster presented at Society of Toxicology 46 th Annual Meeting, Charlotte , NC , 25-29 March 2007
[no DOI]
Bernstein DI; Ott MG; Woolhiser M; Lummus Z; Graham C
Evaluation of antibody binding to diisocyanate protein conjugates in a general population
Ann. Allergy Asthma Immunol., Vol. 97, Sept., 2006, 357-64
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Malo J-L; L’Archevéque J; Lummus Z; Bernstein D
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J.Allergy Clin.Immunol., Vol. 118, (2), Aug., 2006, 530-3
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Pauluhn J; Brown WE; Hext P; Leibold E; Leng G
Analysis of biomarkers in rats and dogs exposed to polymeric methylenediphenyl diisocyanate (pMDI) and its glutathione adduct
Toxicology, Vol. 222, (3), 2006, 202-12
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Bernstein DI; Ott MG; Koke M; Graham C; Woolhiser M; Lummus ZL
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Poster presented at American Thoracic Society 100th International Conference, San Diego, 20-25 May, 2005
[no DOI]
Gledhill A; Wake A; Hext P; Leibold E; Shiotsuka R
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Xenobiotica, Vol.35, (3), Mar., 2005, 273-92
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Pauluhn J
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Poster presented at Society of Toxicology 44th Annual Meeting, New Orleans, 6-10 March, 2005
[no DOI]
Pauluhn J; Woolhiser MR; Bloemen L
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Lee Y-M; Kim H-A; Park H-S; Lee S-K; Nahm D-H
Exposure to toluene diisocyanate (TDI) induces IL-8 production from bronchial epithelial cells: effect of pro-inflammatory cytokines
J.Kor.Med.Sci., Vol. 18, (6), Dec., 2003, 809-12
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Lummus ZL; Park HS; Brown WE; Jolly AT; Biagini RE; Wanner MA; Lewis DM; Burkert AL; Daftarian H; Bernstein DI
Interlaboratory agreement of toluene diisocyanate (TDI)-specific serum antibody results are strongly influenced by antigen characteristics
J.Allergy Clin.Immunol., Vol.111, (2), Suppl., Feb., 2003, S193, Abs.501
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Toxicology of toluene diisocyanate
Appl.Occup.Environ.Hyg., Vol.17, (12), Dec., 2002, 846-55
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Kilgour JD; Rattray NJ; Foster J; Soames A; Hext PM
Pulmonary responses and recovery following single and repeated inhalation exposure of rats to polymeric methylene diphenyl diisocyanate aerosols
J.Appl.Toxicol., Vol.22, 2002, 371-85
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Lemière C; Romeo P; Chaboillez S; Tremblay C; Malo J-L
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Reisser M; Schmidt BF; Brown WE
Synthesis, characterization, and solvolysis studies of mono- and bis-S-(glutathionyl) adducts of methylene-bis-phenylisocyanate (MDI)
Chem.Res.Toxicol., Vol.15, (10), 2002, 1235-41
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Gledhill A; Wake A; Hext P; Leibold E; Shiotsuka R
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Poster presented at Eurotox 2002 Congr., Budapest, 15-18 Sept., 2002
[no DOI]
Park H-S; Lee S-K; Kim H-Y; Nahm D-H; Kim S-S
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Clin.Exp.Allergy, Vol.32, (4), 2002, 551-5
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Park H-S; Cho S-H; Hong C-S; Kim Y-Y
Isocyanate-induced occupational asthma in far-east Asia: pathogenesis to prognosis
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Nakashima K; Takeshita T; Morimoto K
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Bernstein DI; Cartier A; Côté J; Malo J-L; Boulet L-P; Wanner M; Milot J; L'Archevéque J; Trudeau C; Lummus Z
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Pauluhn J; Gollapudi B; Hammond T; Linscombe A, Thiel A; Zischka-Kuhbier D
Bone marrow micronucleus assay in Brown-Norway rats exposed to diphenyl-methane 4,4'-diisocyanate
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Park H-S; Kim H-Y; Lee S-K; Kim S-S; Nahm D-H
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Gamer A; Hellwig J; Doe JE; Tyl RW
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Brown WE; Gamaluddin S; Kennedy AL
Antibody testing: analysis of the specificity of antibody detection in a non-diisocyanate-exposed population
Paper, Symposium on Isocyanates: Sampling, Analysis and Health Effects, Orlando, 26-27 Oct., 2000. ASTM STP 1408, Lesage J et al. eds.
[no DOI]
Chappelle AH; Shiotsuka RN; Bartels MJ
Some limitations in the use of urine biomonitoring for measuring TDI exposure
Paper, Symposium on Isocyanates: Sampling, Analysis and Health Effects, Orlando, 26-27 Oct., 2000. ASTM STP 1408, Lesage J et al. eds.
[no DOI]
Jolly A; Bramann D; Hoffarth H-P
Patch testing for isocyanates
Paper, Symposium on Isocyanates: Sampling, Analysis and Health Effects, Orlando, 26-27 Oct., 2000. ASTM STP 1408, Lesage J et al. eds.
[no DOI]
Aul DJ; Bhaumik A; Kennedy AL; Brown WE; Lesage J; Malo J-L
Specific IgG response to monomeric and polymeric diphenylmethane diisocyanate conjugates in subjects with respiratory reactions to isocyanates
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Bernstein DI; Jolly A
Current diagnostic methods for diisocyanate induced occupational asthma
Amer.J.Ind.Med., Vol. 36, 1999, 459-68
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Analysis of the specificity of antibody detection in relation to diisocyanate asthma
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Pauluhn J; Dearman R; Doe J; Hext P; Landry TD
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Pauluhn J; Emura M; Mohr U; Popp A; Rosenbruch M
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Park H-S; Jung K-S; Kim H-Y; Nahm D-H; Kang K-R
Neutrophil activation following TDI bronchial challenges to the airway secretion from subjects with TDI-induced asthma
Clin.Exp.Allergy, Vol. 29, (10), 1999, 1395-401
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New advances in the pathogenesis of isocyanate-induced occupational asthma
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Developmental toxicity evaluation of inhaled toluene diisocyanate vapor in CD rats
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Tyl RW; Neeper-Bradley TL; Fisher LC; Dodd DE; Pritts IM; Losco PE; Lyon JP; Landry TD
Two-generation reproductive toxicity study of inhaled toluene diisocyanate vapor in CD rats
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In vivo skin decontamination of methylene bisphenyl isocyanate (MDI): soap and water ineffective compared to propylene glycol, polyglycol-based cleanser, and corn oil
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[no DOI]
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